As we age, shifting hormone levels can affect skin health. At HerMD, we understand these changes aren’t just cosmetic—they can affect how you feel in your own skin.
Shifting hormones, especially lower estrogen levels, can lead to:
- Thinner, drier skin
- Fine lines and wrinkles
- Loss of elasticity and firmness
- Changes in tone and texture
- Decreased hydration and acne breakouts
- Delayed wound healing
- Increased sensitivity and irritation
At HerMD, we offer evidence-based treatments through HerMD Pharmacy to support your skin during this transition, including an estrogen face cream and a tretinoin-niacinamide-hyaluronic acid complex.
Estrogen Face Cream
Topical estrogen has been shown to offer several benefits for aging skin.
Key Benefits
- Targets skin changes from menopause and perimenopause by providing localized estrogen support
- Improves hydration and elasticity so skin feels smoother and looks more radiant
- Supports collagen production to help skin appear firmer and regain volume
- Reduces the appearance of fine lines and wrinkles, helping skin appear youthful and revitalized
What the Research Says
In a small study of 59 women, using an estrogen-containing facial cream for six months improved skin elasticity, firmness, and moisture, while wrinkle depth and pore size decreased by 61 to 100%.
In a recent randomized clinical trial investigating the effects of estrogen-containing facial creams, after 12 weeks, individuals who applied an estriol-containing product saw significant improvements in skin elasticity, hydration, and texture, with the skin appearing firmer, plumper, and smoother.
See the Difference
The contrasting pictures of the identical twins shown below highlight the impact of estrogen-containing therapy on skin health.
Twin B (right) used hormone therapy for 22 more years than her sister (left) and appears noticeably younger, demonstrating how this hormone helps keep skin firm, hydrated, and youthful.
Source: Guyuron B, Tucker T, Davis J, et al. Factors contributing to the facial aging of identical twins. Plast Reconstr Surg. 2009;123(4):1321-1330. doi:10.1097/PRS.0b013e31819f56fd
Tretinoin-Niacinamide-Hyaluronic Acid Complex
A tretinoin, niacinamide, and hyaluronic acid trio delivers comprehensive anti-aging results, helping calm, smooth, hydrate, and even skin tone.
Key Benefits
- Tretinoin → stimulates cell turnover, smooths fine lines, supports collagen, and unclogs pores
- Niacinamide → calms redness, strengthens the skin barrier, improves tone, and reduces discoloration
- Hyaluronic Acid → draws in moisture, plumps skin, and counteracts dryness from tretinoin
What the Research Says
A double-blinded clinical study found that treatment with a niacinamide-containing regimen significantly
improved facial skin texture at 4 and 12 weeks and noticeably reduced dark spots by 8 weeks in women ages 35–60.
Before (left) and after (right) 12 weeks of using a niacinamide-containing product. Notice smoother skin and fewer dark spots.
Source: Matts, Paul & Oblong, John & Bissett, D.L.. (2002). A Review of the range of effects of niacinamide in human skin. Int Fed Soc Cosmet Chem Mag. 5. 285-289.
In another randomized clinical study, the addition of a hyaluronic acid containing serum increased skin hydration by 134% immediately after application, with a sustained increase of 55% at week 6, and additional improvements noted in skin smoothness, plumping, fine lines, and overall appearance.
(c) Before hyaluronic acid treatment, left side of the face.
(f) After 6 weeks of hyaluronic acid treatment, left side of the face: increased light reflection (facial shine) due to smoother skin surface and reduction in fine lines.
Source: Draelos ZD, Diaz I, Namkoong J, Wu J, Boyd T. Efficacy Evaluation of a Topical Hyaluronic Acid Serum in Facial Photoaging. Dermatol Ther (Heidelb). 2021;11(4):1385-1394. doi:10.1007/s13555-021-00566-0
Harness the power of this dynamic duo—Estrogen Face Cream and the Tretinoin–Niacinamide–Hyaluronic Acid Blend—to rejuvenate your skin from every angle. Together, they replenish moisture, smooth fine lines, refine texture, and promote firmness, leaving your skin healthier, stronger, and more radiant.
Available through HerMD Pharmacy, these prescription treatments are tailored to your unique needs with guidance from your HerMD provider, so you can feel confident in your skin at every stage of life.
Disclaimer: HerMD offers access to compounded medications that have not been approved by the FDA. The FDA does not evaluate the safety or effectiveness of compounded medications. These formulations are prescribed based on science, real-world outcomes, and clinical expertise. In close collaboration with our pharmacy partner, licensed pharmacists prepare every medication following the highest quality standards and rigorous regulatory protocols to guarantee safety and consistency. To access treatment, patients must schedule an appointment with a licensed HerMD provider, who will determine if a prescription is appropriate based on individual needs. The actual cost to the patient will vary based on the prescribed medication.